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Product name |
 Bb Plus MicroVue™ Quidel® |
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Bb fragments of Factor B of the Alternative Complement Pathway
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Cat-No. |
A027 |
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Range |
0.06 - 0.65 µg/ml |
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Sensitivity |
LOD: 0.018 µg/ml; LLOQ: 0.033 µg/ml |
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Incubation time |
1,5 Stunden |
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Sample volume |
100 µl (after dilution 1:10 for plasma, 1:20 for serum) |
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Sample type |
Serum and plasma
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Sample preparation |
Specimens should be tested immediately or stored at 4 ºC or on ice until assayed. This should not exceed four hours.
For long-term storage, freeze at -70ºC within two hours after collection.
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Reference values |
in Plasma 0.49 - 1.42 µg/ml (+2 SD)
in Serum 0.80 - 6.26 µg/ml (+2 SD)
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Species |
Human, cynomolgus macaque, baboon, rhesus macaque
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Specificity |
Monoclonal mouse-antibody, specifically binds Bb.
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Tests |
96 Tests |
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Method |
ELISA |
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Product informations |
- Literature: Complement Diagnostics (pdf-File 1,850 kb)
- Kit Instructions (pdf-File 193 kb)
- Cross-reaction all species (pdf-File 71 kb)
- Datasheet (pdf-File 511 kb)
- Information (pdf-File 680 kb) |
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Intended use |
The Bb fragment enzyme immunoassay measures the amount of the complement fragment of Bb, an activation fragment of Factor B in human plasma or serum, as well as in other biological fluids, experimental samples or mixtures. This measurement allows a quantitative assessment of the extent of activation of the alternative pathway of complement in the test sample. Measurement of alternate pathway activation aids in the diagnosis of several kidney diseases (e.g. chronic Glomerulonephritis, lupus nephritis), as well as several skin diseases (e.g. dermititis herpetiformis and pemphigus vulgaris). Other diseases in which activation of the alternat pathway of complement has been observed include rheumatoid arthritis, sickle cell anemia,
and gram-negative bacterial infections.
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Keywords product |
Bb Plus, ELISA, Bb fragments of Factor B of the alternative pathway, Complement product, Complement pathway, Complement cascade, ASTM F1984-99, ASTM F2065-00
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